ETP-ALL is a subtype of T-ALL/LBL formed from thymic cells in the early T-cell precursor (ETP) development stage, which have the ability to specialise into several lineages, including lymphoid and myeloid. ETP-ALL is responsible for 15% of paediatric T-ALL and 10% to 30% of adult T-ALL. CD7 immunophenotypic expression, a lack of CD1a and CD8, weak CD5 expression (with 75% positive blasts), and positive expression of one or more stem cell or myeloid markers, such as CD117, HLADR, CD13, CD33, CD11b, or CD65, are all present. A well-defined gene expression signature, which includes DNMT3A and FAT3 mutations, identifies ETP-ALL. With a brief review of the literature, we present two cases of ETP-ALL.
Author(S) Details
Surabhi
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
A. Singh
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
J. Singh Nigam
Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.
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