Introduction: Diabetes duration, advanced glycation end products (AGEs), and glycemic control all play a role in the development of vascular problems, which are linked to morbidity and mortality in diabetic patients. As a result, it's critical to understand the links between serum fluorescence of advanced glycation end products, glycemic control, microvascular problems, and diabetes mellitus duration. Diabetic patients of a higher age with poorer glycemic control and longer diabetes duration had significantly increased serum fluorescence of AGEs and a higher prevalence of microvascular problems. The length of the condition, hypercholesterolemia, high levels of low density lipoprotein, hypertension, and the patients' socioeconomic level were all linked to poor glycemic control. The serum fluorescence of AGEs, the duration of diabetes mellitus, glycated haemoglobin, and fasting glucose levels have all been reported to have significant positive associations. In older patients with longer diabetes duration who are at increased risk of developing diabetic microvascular complications, stringent glycemic control and therapeutic options that target molecular pathways involving AGEs are recommended, according to important study findings.
Author(S) Details
Nivedita L. Rao
Department of Biochemistry, Yenepoya Medical College, Yenepoya (deemed to be University), Deralakatte, Mangalore, Karnataka, India.
Greeshma B. Kotian
Department of Biochemistry, Yenepoya Medical College, Yenepoya (deemed to be University), Deralakatte, Mangalore, Karnataka, India.
Shaheena Yasser
Department of Biochemistry, Yenepoya Medical College, Yenepoya (deemed to be University), Deralakatte, Mangalore, Karnataka, India
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