Understanding muscle bioenergetics requires identifying mitochondrial roles and regulatory mechanisms, which is a key challenge in physiology/pathophysiology. Microtubules, intermediate filaments, and microfilaments are three cytoskeletal structures that play a critical role in mitochondrial structure/architecture, intracellular organisation, and motility. Furthermore, various cytoskeleton-mitochondrial contacts can actively contribute to the regulation of mitochondrial respiratory activity and oxidative phosphorylation (OXPHOS). Mitochondrial locations are strongly established in skeletal and cardiac muscles, with fairly regular organisation along filaments, providing a foundation for many interactions with cellular systems such as the cytoskeleton and sarcoplasmic reticulum (SR). Importantly, this could entail cytoskeletal components interacting with VDAC (the voltage-dependent anion channel), influencing the permeability of the outer mitochondrial membrane (OMM) and overall mitochondrial energy metabolism in this way. In contrast to other tubulin isoforms, cardiac muscles and isolated cardiomyocytes display a regular arrangement of tubulin beta-II entirely co-localized with mitochondria. This data points to tubulin beta-involvement II's in the modulation of OMM permeability via interaction with VDAC. Furthermore, the particular isoform of the cytoskeletal protein plectin may modulate OMM permeability. The importance of the cytoskeleton in the regulation of energy metabolism and mitochondrial physiology, as well as OXPHOS and intracellular energy transfer, is summarised and discussed in this book chapter.
Author (s) DetailsAndrey V. Kuznetsov
Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria and Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Sabzali Javadov
Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA.
Michael J. Ausserlechner
Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Judith Hagenbuchner
Department of Paediatrics II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
View Book :- https://stm.bookpi.org/RRAB-V8/article/view/1200
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