Hand Book on Normal Anatomy, Anatomical Variants and Most Common Congenital Heart Defects: A Light House to Cardiac Surgeon | Book Publisher International

 

Cardiac diseases are widely prevalent worldwide and are the main causes of death especially in developing countries. So, knowledge of normal and variant along with congenital anomalies of the heart is essential for cardiologists. Clinicians due to their busy schedules, it is not possible for them to go through the entire literature to diagnose cardiac diseases. In this book, almost all the information related to the human heart is consolidated which will act as a ready reference to cardiologists easing them to diagnose the diseases easily.

Author(s) Details

Dr. Rajani Singh
Department of Anatomy, UP University of Medical Sciences Saifai, Etawah 206130, UP, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48006-35-6

Targeting Adrenergic Receptors in Metabolic Therapies for Heart Failure: A Review | Chapter 1 | Current Practice in Medical Science Vol. 3

When the heart fails, it is unable to produce enough energy, leaving the body in an energy-starved state with reduced functioning. Numerous modifications to the metabolic pathways in the failing heart that result in a decrease in the oxidation of either glucose or fatty acid substrates have been found in studies. Diminished energy production is needed to mediate cardiac contraction as a result of this reduced oxidation, which results from abnormalities in mitochondrial activities and/or oxidative phosphorylation. Early-stage clinical studies have demonstrated that fatty acid oxidation inhibitors and antioxidants that target the mitochondria improve cardiac function during failure by increasing compensatory glucose oxidation. Adrenergic receptors (α₁ and β) are a crucial regulator of the sympathetic nervous system that controls heart function. Both β-AR blockers and α-_1A-AR agonists have potential therapeutic use in the treatment of heart failure. In addition to regulating inotropy and chronotropy, the heart's α¹- and β2-adrenergic receptors also regulate metabolic processes that have a positive impact on the heart. In this review, we highlight new research that show how metabolic pathways regulated by adrenergic receptors may be able to restore cardiac energetics to non-failing levels, suggesting potential treatment approaches.

Author(s) Details:

Dianne M. Perez,

The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, US.

Please see the link here: https://stm.bookpi.org/CPMS-V3/article/view/7379

The Heart - the Source of All Life | Book Publisher International

 As a radio station, the heart can emit waves to other hearts and receive waves in various frequencies from the sun and other hearts via its electro-magnetic field. Good emotions such as love, forgiveness, gratitude, and joy help to keep the heart healthy, however negative emotions such as anger, fear, hate, and envy can harm the heart and lead to heart disease. In Islam and Sufism, a pure heart is crucial, as it is required to sense Allah's presence. Bad desires must be eradicated from the heart. All religions contain elements of mysticism. Sufism, as a mystical branch of Islam, exemplifies the heart's linking abilities. The heart has a vital role in Islam, as we can see from the Koran. Philosophy, psychology, and medicine must recognize that the soul resides in the heart, not the brain, and that treatment should be directed toward the heart.

Author(s) Details

Kurt Hünting
Building Number: 2, Street Number: Schillerstraße, Any Nearby Landmark: Lower Rhine, Rees, Kreis Kleve, NRW (Nordrhine-Westfalia) 46459, Germany.

View Book:- https://cls.bookpi.org/index.php/THSAL/article/view/7

Mitochondrial Involvement in the Molecular Mechanisms of Ischemia-Reperfusion Injury in the Heart | Chapter 6 | Recent Research Advances in Biology Vol. 8

 Mitochondria are responsible for maintaining cell viability and essential biological activities by producing energy (ATP). These organelles are also a major source of reactive oxygen species (ROS) and a number of apoptosis inducers. The importance of mitochondria in a variety of areas of cell physiology and pathology, such as intracellular signaling, has been demonstrated. Mitochondria and mitochondrial function can decline as a result of pathological situations such as illness, ischemia-reperfusion injury, and ageing. Due to numerous cell stressors, creation of excess ROS (oxidative stress), elevated cellular and mitochondrial calcium levels, and apoptotic or necrotic cell death, damaged or injured mitochondria are the main causes of cell and tissue abnormalities. Under normal and pathological settings, the relationship between these mitochondrial activities has yet to be identified. Mitochondria are intimately implicated in a variety of pathophysiological pathways in cardiac IR injury. The role of mitochondrial dynamics (fission, fusion) and heterogeneity is discussed here. We emphasise the existence of functionally distinct mitochondrial subpopulations in the heart and skeletal muscles, which may have varied susceptibility to illnesses and IR injury. As a result, various cardioprotective medications that maintain mitochondrial stability, dynamics, and turnover, such as several agents, specific mitochondrial antioxidants, uncouplers, and the use of ischemic preconditioning, may be considered as possible, beneficial strategies to protect mitochondria and cardiac function and extend lifespan.

Author (s) Details

Andrey V. Kuznetsov
Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria and Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Sabzali Javadov
Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA.

Michael J. Ausserlechner
Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Judith Hagenbuchner
Department of Paediatrics II, Medical University of Innsbruck, 6020 Innsbruck, Austria.

View Book :- https://stm.bookpi.org/RRAB-V8/article/view/1201

The Role of Cytoskeletal Proteins in the Regulation of Mitochondrial Function | Chapter 5 | Recent Research Advances in Biology Vol. 8

 Understanding muscle bioenergetics requires identifying mitochondrial roles and regulatory mechanisms, which is a key challenge in physiology/pathophysiology. Microtubules, intermediate filaments, and microfilaments are three cytoskeletal structures that play a critical role in mitochondrial structure/architecture, intracellular organisation, and motility. Furthermore, various cytoskeleton-mitochondrial contacts can actively contribute to the regulation of mitochondrial respiratory activity and oxidative phosphorylation (OXPHOS). Mitochondrial locations are strongly established in skeletal and cardiac muscles, with fairly regular organisation along filaments, providing a foundation for many interactions with cellular systems such as the cytoskeleton and sarcoplasmic reticulum (SR). Importantly, this could entail cytoskeletal components interacting with VDAC (the voltage-dependent anion channel), influencing the permeability of the outer mitochondrial membrane (OMM) and overall mitochondrial energy metabolism in this way. In contrast to other tubulin isoforms, cardiac muscles and isolated cardiomyocytes display a regular arrangement of tubulin beta-II entirely co-localized with mitochondria. This data points to tubulin beta-involvement II's in the modulation of OMM permeability via interaction with VDAC. Furthermore, the particular isoform of the cytoskeletal protein plectin may modulate OMM permeability. The importance of the cytoskeleton in the regulation of energy metabolism and mitochondrial physiology, as well as OXPHOS and intracellular energy transfer, is summarised and discussed in this book chapter.

Author (s) Details

Andrey V. Kuznetsov
Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria and Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Sabzali Javadov
Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USA.

Michael J. Ausserlechner
Department of Paediatrics I, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Judith Hagenbuchner
Department of Paediatrics II, Medical University of Innsbruck, 6020 Innsbruck, Austria.

View Book :- https://stm.bookpi.org/RRAB-V8/article/view/1200

Exploring the Parallels between Christina Rossetti's Literary and Somatic Expressions of Graves' Disease | Chapter 9 | New Horizons in Education and Social Studies Vol. 4

 

Christina Rossetti (1830-1894), a Victorian poet, was always plagued by poor health, and her mid-life episode of life-threatening illness (1870-1872) when she suffered from Graves' illness provides an illuminating case study of the ways in which poetry and prose can represent illness. Rossetti, her relatives, and her doctors understood the disease of Graves as a heart condition; but the writing of Rossetti represents a different model, introducing themes of self-attack and a fractured self that uncannily echo the current perception of the disease of Graves as autoimmune in nature. Interestingly, these imaginative depictions indicate an interpretation of this disease mechanism that could not have been understood through Rossetti's family records and the history of Victorian medicine. Rossetti 's writing started to use modern rhetoric and imagery of self-acceptance and hardship as a way of personal improvement after the crisis had ended. This essay addresses the similarities that exist between Literary and somatic metaphors: the body and art of Rossetti are always "saying" the same thing simultaneously, the physical symptoms somatically reflecting the same dynamic reflected in Rossetti 's artistic writing in metaphor and narrative. Such a well-documented history of cases poses concerns about how paradigms of disease that are not available to the conscious mind can influence writing. We currently accept that the unconscious mind can be an significant source of artistic creativity: is it possible that the unconscious physical operations of the body in a creative person may also be a source of metaphor? This diverse subject is truly interdisciplinary, as we aim to better understand ways of transmitting disease, raising questions in fields ranging from medicine and cognitive science to philosophy, language theory, literary critique, and aesthetics.

Author (s) Details

Mary Arseneau
Department of English, Hamelin Hall, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Dr. Emery Terrell
Faculty of Medicine, Roger Guindon Hall, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

View Book - https://bp.bookpi.org/index.php/bpi/catalog/book/280