Background: Poor socio-economic, early
marriage, poor acceptance of contraceptives, poor spacing of pregnancies, high
fertility rate and poor maternal and child health indices in developing
countries such as Nigeria, leading to poor maternal-child outcome. There are
physiological changes in TG metabolism during pregnancy that could be linked to
increased metabolic rate. The pattern of serum lipid changes during pregnancy
in women in Nigeria needs to be examined as hyperlipidemia may lead to poor
maternal outcome. Materials and Methods: A total of one hundred and forty (140)
participants between the ages of 20 and 45 with a mean sample population age of
29.74 ± 6.5 years. Group 1: The control consists of 35 (35) stable non-pregnant
subjects with a mean age of 26.84 ± 5.2 Nigerian-born volunteers. Group 2: One
hundred and five (105) seemingly healthy pregnant Nigerian women were included
in the test, subdivided into three groups; X, Y and Z each comprised
thirty-five (35) subjects divided into the first, second and third trimesters
of pregnancy. As defined by Biosystems, the TG assay was analysed using the
enzymatic spectrophotometric method. Performance: The results of the study
showed a substantial rise in TG levels (p ≤ 0.05) during the
first trimester of pregnancy relative to control levels as shown in Table 1.
During the second trimester of pregnancy, there was a substantial rise (p ≤ 0.05) in TG levels compared with those of the control subjects. Compared with
control subjects, there was a substantial rise in TG levels during the third
trimester of pregnancy. Conclusion: This research showed that the most
significant shift in the lipid profile during normal pregnancy was serum
hypertriglyceridemia, which in the third trimester may be as high as two-three
times the level in non-pregnant subjects. Since recent studies have blamed
irregular lipid metabolism during pregnancy for atherosclerotic pathogenesis,
cardiac ischemia, intrauterine growth disease, intrauterine growth retardation,
and hypertension. This research illuminates the potential cause of developing
preeclampsia and brings it to understanding. As part of regular antenatal
tests, the lipid profile may be recommended and, if possible, accepted by the
Clinical Services Department of this organisation. In pregnancy, this can
minimise or even remove complications of hyperlipidemia.
Author(s) Details
Affi Ayuba
Department of Chemical Pathology, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
Mutihir Josiah
Department Obstetrics and Gynaecology, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
Dalili Shabbal
Department of Chemical Pathology, College of Health Sciences, University
of Abuja, Abuja, Nigeria.
Pam Stephen
Department of Radiology, College of Health Sciences, Jos University
Teaching Hospital Jos, Nigeria.
Amusa Ganiyu
Department of Internal Medicine, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
Longwap
Abdulazeez Saleh
Department of Chemical Pathology, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
Mercy Solomon
Department of Chemical Pathology, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
A. Lukdem
Department of Chemical Pathology, College of Health Sciences, Jos
University Teaching Hospital Jos, Nigeria.
T. Solewo
Department of
Chemical Pathology, College of Health Sciences, Jos University Teaching
Hospital Jos, Nigeria.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/361