Wound healing is a complex physiological process that can be
disrupted by pathological conditions, causing chronic wounds when they
represent a significant burden on health systems. Marine-based biopolymers,
particularly chitosan and alginate, have attracted attention as wound care
biomaterials due to their properties, such as being biocompatible and
biodegradable with intrinsic bioactivities. Nutritional interventions are also
predominantly carried out to promote the wound-healing process, and this chapter
provides a detailed panorama on the clinical uses of chitosan and alginate,
which are already utilised in wound healing amidst nutritional interventions as
observed. The present study describes mechanisms of action along with
haemostatic, antimicrobial, anti-inflammatory and regenerative effects. The
chapter summarises the experimental and clinical evidence, including randomised
controlled trials, showing that chitosan-based dressings are effective in
promoting healing of chronic ulcers such as diabetic foot ulcers. Instead, with
clinical experience, alginate dressings used in high-exudate wounds are shown
as beneficial; yet, systematic reviews revealed that this type of dressing did
not promote healing rates better than other alternative modern dressings. It
also addresses the synergetic effects of a composite dressing that consists of
chitosan and alginate, as they demonstrate superior mechanical and therapeutic
features in preclinical models. Oral chitosan and alginate are nutritional
supplements that are generally believed to promote wound healing (although this
is speculative without clear clinical evidence). Future studies could enable
the development of “smart” dressings, and larger, more definitive clinical
trials are required to realise the true potential of these marine-derived
biomaterials in advanced wound care.
Author(s) Details
A. A. Zubair
PG and Research Department of Aquaculture and Fishery Microbiology, MES
Ponnani College, Ponnani South, Malappuram, India.
Please see the book here :- https://doi.org/10.9734/bpi/rpbs/v10/7253
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