Serum Testosterone Levels and Their Relationship with Body Mass Index in Male Patients with Chronic Kidney Disease: A Comparative Cross-Sectional Study | Chapter 5 | An Overview of Disease and Health Research Vol. 10

 

Introduction: Chronic kidney disease (CKD) represents a significant disorder that affects multiple vital organs and physiological systems, with endocrine dysfunction being a common associated complication. The altered metabolic milieu in CKD affects the secretion of hormones and the response of target tissues, causing endocrine dysfunctions. Early identification of patients with chronic kidney disease (CKD) may help implement interventions to decrease progression and eventual morbidity and mortality. Most previous studies investigating testosterone abnormalities and renal disease have concentrated on patients with end-stage renal disease (ESRD), and little is known about the problem’s pervasiveness in patients in the pre-dialysis phase.

 

Aim of the Study: This study aimed to evaluate the serum testosterone level of adult males with different stages of CKD and its association with body mass index, and comparison with age-matched healthy individuals.

 

Methods: This cross-sectional study was conducted in the Department of Nephrology, Dhaka Medical College Hospital, Dhaka, Bangladesh. All CKD patients were designated as group ‘A’ with 90 cases; the healthy control group were grouped as group ‘B’ with 88 cases. Statistical analyses were conducted using the Statistical Package for Social Sciences version 16.0.

 

Results: In this study, the majority 40(44.4%) of patients had glomerulonephritis, 24(26.8%) had DM and 11(12.2%) had HTN. The mean BMI was found to be 20.85±2.7 kg/m2. More than two-thirds (66.7%) of patients had normal (3.2-14.6 ng/ml) Serum testosterone, and their mean Serum testosterone was found at 4.29±1.9 ng/ml. Negative Spearman’s rank correlation (r=-0.893; p=0.001) was observed between different stages of CKD and S. Testosterone of CKD patients. A positive Pearson correlation existed (r=0.517; p=0.001) between BMI and S. Testosterone of CKD patients.

 

Conclusion: A significant positive correlation existed between BMI and serum testosterone in CKD patients. Future studies are needed to determine the potential adverse effects of low serum testosterone levels in patients with chronic kidney disease and to determine whether the therapeutic intervention of low serum testosterone in males with chronic kidney disease.

 

 

Author(s) Details

E. A. F. Ansary
Department of Nephrology, Uttara Adhunik Medical College, Dhaka, Bangladesh.

 

M. N. Islam
Department of Nephrology, Mugda Medical College, Dhaka, Bangladesh.

 

M. A. Kader
Department of Medicine, Bangladesh Medical University, Dhaka, Bangladesh.

 

O. K. Uzzal
Department of Medicine, Jashore Medical College, Jashore, Bangladesh.

 

S. Masood
Department of Physiology, Jahurul Islam Medical College, Kishoreganj, Bangladesh.

 

F. Jahan
Department of Nephrology, Bangladesh Medical University, Dhaka, Bangladesh.

 

M. N. Chowdhury
Department of Nephrology, BRB Hospital, Dhaka, Bangladesh.

 

Please see the book here :- https://doi.org/10.9734/bpi/aodhr/v10/7072