Substituted Arylidene Imidazolones: Synthesis, Spectral Characterization and Molecular Docking Studies | Chapter 7 | Chemistry and Biochemistry: Research Progress Vol. 9

 

Ten analogues of acetylphenyl tethered imidazolones (4.12a-j) from 4-arylidene-2-phenyloxazol-5(4H)-ones were prepared and characterised by IR, 1HNMR, 13CNMR and mass spectra. All the analogues have shown moderate to good antibacterial activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus. By means of FabI of S. aureus, docking studies were carried out. Altogether, the compounds were proven to be inhibitors of enoylacylcarrier proteinreductase.

 

 

Author(s) Details

Y. Aparna
Matrusri Engineering College, Saidabad, Hyderabad, Telangana, India.

 

N. J. P. Subhashini
Department of Chemistry, Osmania University, Hyderabad, Telangana, India.

 

Please see the book here :- https://doi.org/10.9734/bpi/cbrp/v9/6759