Hepatitis E virus (HEV) is a small virus belonging to the
family Hepeviridae. The genome of HEV is a single-stranded, positive-sense RNA
about 15 kb in length and is categorized into three open reading frames (ORFs):
ORF1 (replicative machinery), ORF2 (viral capsid) essential for (infectious
particle formation) and ORF3 (viral release), encoding both structural and
non-structural proteins. The fourth ORF4 has been demonstrated to play a
critical role in the viral replication in genotype 1 (GT 1) isolates of HEV.
Due to insufficiency in appropriate HEV in vitro cell culture systems, our
knowledge of its pathogenesis is inadequately understood. The current
introductory chapter briefly focuses on the novel ORF4 along with its functions
known to date based on the newest published literature. The information
provided in this review on the HEV ORF4 protein is likely to assist in
understanding the deeper functioning of HEV biology.
Author(s) Details
Zoya Shafat
Centre for Interdisciplinary Research in Basic Sciences,
Jamia Millia Islamia, New Delhi 110025, India.
Please see the link:- https://doi.org/10.9734/bpi/mono/978-81-976007-3-9/CH1
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