Determination of Cytological and P53 Expression Effects after Waterpipe Using | Chapter 8 | Current Innovations in Disease and Health Research Vol. 7

 The aim of this investigation search out look into the cytological alterations and p53 verbalization in oral mucosa with waterpipe users in the Kingdom of Saudi Arabia (KSA). Waterpipe smoking is a standard activity with young adults worldwide and has happened linked to miscellaneous health problems. Tobacco is individual of the most important risk determinants for premature death everywhere. More than 60 toxic chemicals in cigarette can invade the body’s various methods. Oral squamous cell abnormal growth in animate being (OSCC) is a pathological type of oral malignancy, accounting for over 90% of oral cancers. A colossal quantity of controlled, clinical and epidemiological data shows that cigarette is associated with the incident of oral squamous cell abnormal growth in animate being, and its carcinogenic pathways grant permission be complicated. A cross-divided study was conducted during January to October 2022 in KSA. Two spoken mucosa samples were collected from 500 suggests, of which 300 were waterpipe consumers and 200 were non-users. Samples were stained utilizing the Papanicolaou staining procedure and immunocytochemical method to show the cytological changes and verbalization of P53. The Papanicolaou staining outcomes told four different results: inflammation, contamination, atypia and keratinization. Cytological inflammation was recognized in 77/300 (25.6%) waterpipe smokers, which was higher than in non-consumers (12/200, 6%). Conversely, cytological infection and atypia were observed more usually in waterpipe smokers than in controls (9% vs. 4.5% and 4.3% vs. 0.5%, respectively), while keratinization was only discovered in waterpipe users (3.6%) compared to non-consumers. Additionally, waterpipe users exhibited larger p53 protein expression distinguished to non-users. These findings indicate that usage of a waterpipe causes specific alterations in the spoken mucosa, containing elevated p53 expression in unusual and keratinizing cells. The likely prognosis of oral mucosal lesions that can be malignant, however, grant permission not be determined alone by the presence or lack of p53 staining.

Author(s) Details:

Faris M. Elmahdi,
Department of Basic Science, College of Medicine, Al Rayyan Colleges, Madinah, Saudi Arabia.

Lina A. Salim,
Department of Anesthesia, College of Health Science, Al Rayyan Colleges, Madinah, Saudi Arabia.

Please see the link here: https://stm.bookpi.org/CIDHR-V7/article/view/12046