The aim of present study search out review on those factors moving solubility, stability and bioavailability of non steroidal anti angering drugs (NSAID) for possible augmentation of therapeutic index (anti-instigative activity) accompanying lesser side effects. That prodrug compound on presidency gets proper synthetic biotransformation or enzymatic adaptation (metabolized) within our body and before converted into pharmacologically alive drug. This active moiety specifies us better therapeutic index or pharmacological conduct in our body in comparison accompanying that of parent drugs. On additional hand, these prodrug forms of drugs are smart to reduce the adverse belongings by masking the carboxylic acid function and different factors positively. On added hand this leads few changes into the pharmacokinetic profiles of drugs that provide us maintained release effects accompanying reduced antagonistic effects in comparison to that of person drugs itself. Thus the present item highlights on those parameters for likely utilization of more recent prodrugs concept for the purpose of eliminating those disadvantages of NSAID drugs and moving toward better consequences and therapeutic index values.
Author(s) Details:
Meenakshi Jaiswal,
Department
of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)- 495009,
Chhattisgarh, India.
Nidhi
Agrawal,
Department
of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)- 495009,
Chhattisgarh, India.
Yogendra Kumar,
Shri Shankaracharya College of Pharmaceutical Sciences, Junvani,
Bhilai, Durg (C.G.) - 490020, Chhattisgarh, India.
S. K. Lanjhiyana,
epartment of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur
(C.G.)- 495009, Chhattisgarh, India.
Please see the link here: https://stm.bookpi.org/COPS-V1/article/view/8961
No comments:
Post a Comment