Adipocytes as a Risk Factor for Metastasis in Patients with Gastric Cancer and Normal Weight | Chapter 5 | Current Practice in Medical Science Vol. 5

 

The study's objective was to determine how the density of cancer-associated adipocytes (CAAs) influences the presence of disseminated tumor cells (DTCs) in the bone marrow (BM) of patients with gastric cancer (GC) who are normal weight (BMI25) and who have the metastatic process. The instability of the tumor microenvironment caused by an excess of CAA density in tumors limits the capacity of cancer cells to spread and develop metastases. However, the majority of these studies focus on obesity, and nothing is known regarding the potential impact of CAAs on metastasis in individuals with GC who have a BMI of 25 or above. Patients with GC were enrolled in the study, and tumor tissue was examined using immunohistochemical techniques. It was discovered that the frequency of DTC availability in BM increased with a statistically significant probability in patients with GC at BMI 25 and tumors distinguished by an excess of CAAs (P 0.05). According to studies, patients with GC and a BMI below 25 who have tumors with a high CAA content are at a greater risk of spreading. Further research is necessary to fully understand the mechanisms underlying the metabolic symbiosis between cancer cells and CAAs in GC patients with BMI25.

Author(s) Details:

L. Bubnovskaya,
R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.

I. Ganusevich,
R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasilkovskaya Str. 45, Kiev-03022, Ukraine.

S. Merentsev,
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.

D. Osinsky,
City Clinical Oncological Center, Verchovynna Str.69, Kiev-03115, Ukraine.

Please see the link here: https://stm.bookpi.org/CPMS-V5/article/view/7653