The capacity of breast cancer cells to develop resistance to chemotherapeutic medications, as well as off-target cytotoxicity of these drugs on normal cells, are major roadblocks in current breast cancer therapy efficacy, resulting in debilitating side effects. The metabolism of cancer cells differs significantly from that of normal cells during carcinogenesis, as cancer cells have changes in glycolytic and mitochondrial metabolism. The following are the goals for each book chapter:
1. Educate yourself on the disease of breast cancer.
2. Distinguish between breast cancer and normal mammary cells in terms of metabolism.
3. Explain how alternative breast cancer treatment strategies based on the use of phytochemicals in combination with DNA-targeting agents could be more effective than DNA-targeting drugs.
To do so, we examine the anti-breast cancer capabilities of three specific phytochemicals, namely cinnamaldehyde, chlorogenic acid, and arctigenin, as a basis for developing a new (Western) strategy to breast cancer treatment by refining an age-old (Eastern) approach to disease therapies. Targeting the mitochondria - and cancer cell metabolism in particular - may result in a more efficient anti-cancer treatment with fewer off-target effects on normal cells, which is why these phytochemical examples are of relevance.Author(S) Details
Caroline Schuster
Department of Biological Sciences, Texas Tech University, Lubbock, Texas, 79407, U.S.A.
Naima Moustaid-Moussa
Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, 79407, U.S.A and Obesity Research Center, Texas Tech University, Lubbock, Texas, 79407, U.S.A.
Lauren S. Gollahon
Department of Biological Sciences, Texas Tech University, Lubbock, Texas, 79407, U.S.A and Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, 79407, U.S.A and Obesity Research Center, Texas Tech University, Lubbock, Texas, 79407, U.S.A.
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