The major goal of this study was to construct bilayer extended release matrix tablets of etoricoxib with a loading dose followed by a maintenance dose, which was intended to improve the medication's therapeutic efficacy while reducing its toxicity. Because most bilayer tablets are created as part of a Life Cycle Management Program, bilayer technology has the potential to extend a drug's patent life. With the careful proportioning of release regulating Hydroxy propyl methyl cellulose K100 (HPMC K100) and lactose, bilayer pills of etoricoxib were successfully created. The pills were made using the wet granulation method. Various formulations required different granules for the immediate and extended layers. The formulations were created, and tests were carried out to see what factors influence the tablets' in vitro performance. A study using Fourier transform infrared spectroscopy (FTIR) was used to establish drug-excipient compatibility.
Physical parameter values for all formulations were found to be within a reasonable range. In the prolonged release layer, a formulation combining HPMC K 100 and lactose in a 2:1 ratio was able to release 26.22 percent of the drug in 15 minutes and maintained a consistent release of the drug for 12 hours. To get the n value, which represents the drug release mechanism, the dissolution data was entered into the Korsemeyer–Peppas model. The n-value of various formulations was discovered to be varied. In the bilayer tablet F8, the Fourier transform infrared spectroscopy (FTIR) research revealed no new peaks and no alterations in the locations of the absorption bands, indicating that there are no significant interactions between etoricoxib and other excipients.
It was determined that an etoricoxib bilayer tablet with immediate and extended release can be created with significant physical and dissolving qualities. As a result, the daily dose of etoricoxib was reduced, lowering the risk of cardiovascular damage.Author(S) Details
Bibaswan Mishra
Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Odisha, India.
Satyajit Panda
Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Odisha, India.
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