Ayurvedic NanoGold Formulation as a Shield against Coronaviruses: Including SARS CoV 2 | Chapter 8 | Recent Developments in Medicine and Medical Research Vol. 11

 Many researchers believe that immunosenescence is to blame for the higher mortality seen in the elderly population during the current SARS-CoV 2 pandemic. SARS-CoV 2 infection causes a variety of symptoms, ranging from asymptomatic mild instances to more serious presentations. Primary immune cell defects and dysfunctions are thought to be the most crucial component in people who acquire the more serious version of the disease. These flaws could be in the PRRs of Dendritic cells' effective and early identification of PAMPs, or in the monocytes' and macrophages' delayed and hyper-inflammatory cytokine release in the lungs. The innate immune system response is currently being touted as a key element in illness prognosis. Even though immunosenescence is thought to be permanent, it is a dynamic process that can be reconditioned and improved. Gold nanoparticles (GNP), which have lately been explored for their ability to act as carriers of vaccinations and chemotherapeutic medicines, are one agent that can reinvigorate the ageing immune system. GNP treatment in rats resulted in an increase in lymphocyte cell populations as well as dendritic cell and macrophage activation. Because immunosenescence induces a reduction of naive T and B cells, GNP may be beneficial. Dendritic cells and macrophages that recognise PAMPs better may be able to generate a more effective response to the invading virus. For millennia, India has employed elemental gold compositions to treat ailments ranging from fevers to memory loss to senility. Because some formulations are suggested for infants, their safety is unquestionable. Such formulations, when modified appropriately, can play a critical role in oral vaccinations against not only Covid 19, but a wide spectrum of other influenza viruses.

Author(S) Details

Sharadendu Bali
General Surgery, MMIMSR, Ambala, India.

Ashish Kumar Choudhary
General Surgery, MMIMSR, Ambala, India.

Vipin Saini
MMSP, MMU, Sadopur, Ambala, Haryana, India.

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