Mobile genetic elements (MGEs) make up a significant portion of eukaryotic DNA, accounting for over 45 percent of the human genome. Numerous studies suggest that these elements have a variety of roles in the genome, ranging from plasticity factors to mutability and stability. They talk about their function in genome evolution and gene regulation evolution. The goal of this study was to look into the distribution of MGEs in the human MGMT gene and how they regulate it. MGEs have been found in both the intron sequences and the promoter region of the human MGMT gene. MGEs produce composite cluster structures in intron sequences, which are a source of diverse regulatory sequences and have the ability to form alternative promoters. Three MGE sequences were found in the promoter region: two LTR-repeats and a DNA-transposon fragment. MGEs fragments in the human MGMT promoter region were likewise enriched with putative cis-regulatory elements that could be involved in the gene's regulation.
Author(S) Details
O. V. Pidpala
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Ukraine.
L. L. Lukash
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Ukraine.
View Book:- https://stm.bookpi.org/RDMMR-V1/article/view/4086
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