Extrapulmonary Tuberculosis: Is Cartridge Based Nucleic Acid Amplification Test More Superior to the Conventional Methods in Diagnosis? | Chapter 14 | Recent Developments in Medicine and Medical Research Vol. 4

 The lymph nodes, pleura, central nervous system, bones, gastrointestinal tract, and genitourinary tract are the most common sites of extrapulmonary tuberculosis [EPTB]. Isolated lymphadenopathy and effusion in the bodily cavities are the most common symptoms. Fine Needle Aspiration Cytology [FNAC], Acid Fast Bacilli [AFB] demonstration by Zeihl-Neelson [Z-N] stain, and Cartridge Based Nucleic Acid Amplification Test [CBNAAT] are all tests used to detect EPTB. The data of 100 clinically suspected EPTB patients who had undergone FNAC, CBNAAT, and Z-N stain in Mandya Institute of Medical Sciences, Mandya, Karnataka, was used in a retrospective record-based analysis. After receiving approval from the Institutional Ethics Committee, the study was conducted for four months, from March to June 2018. The analysis found 47 situations where FNAC results favoured EPTB. Thirty of the 47 cases tested positive for CBNAAT. Out of 53 instances with negative FNAC results, 5 had positive CBNAAT. Only 13 of the 35 CBNAAT positive individuals tested positive for AFB. To summarise, because of its high specificity and positive predictive value, CBNAAT is a quick, accurate, and simple test for early detection of EPTB. CBNAAT can also detect cases that FNAC and Z-N stain couldn't.

Author(S) Details

M. U. Mythreyi
Mandya Institute of Medical Sciences, Mandya, Karnataka, India.

M. S. Siddegowda
Mandya Institute of Medical Sciences, Mandya, Karnataka, India.

S. Shivakumar
Mandya Institute of Medical Sciences, Mandya, Karnataka, India.

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