Goal: The aim of this study was to understand the relationship between the characteristics of circadian blood pressure rhythm (BP) and renal function in subjects with diabetic and non-diabetic stage III chronic kidney disease ( CKD). Materials and Methods: This study enrolled a total of 30 CKD-hypertensive diabetes-free patients and 30 Type 2 diabetic patients with overt diabetic nephropathy (DN). From 24 h ambulatory BP monitoring, the values of BP variability were obtained. Results: As a result of thorough patient evaluation and statistical data processing, the ratio of albumin to creatinine in the urine was found to be significantly higher in the group of patients with DN than in the group of patients with non-DN (4.08 ± 6.15) mg / g and (1.43 ± 2.94) mg / g. Author(s) Details Compared to the non-DN group (2.72 ± 1.53) mmol / L and (1.55 ± 1.14) mmol / L, respectively, mg / g is substantially higher than triglycerides. An significant frequency was that patients with non-DN appeared to decrease their BP in the morning, and thus the morning increase in systolic BP (SBP) and diastolic BP (DBP) was negative (-4.88 ± 21.35) mm Hg and (-70.88 ± 14.35) Hg respectively in this community of patients. These parameters surpass the standard in DN patients and are equal to SBP (66.02 ± 21.48) mm Hg and DBP (57.13 ± 12.75) mm Hg. The mean daily diastolic pressure was significantly higher in the group of patients with DN than in the non-DN group ([124.50 ± 33.78] and [111.50 ± 11.5] mm Hg, P < 0.05), with significantly lower SBP variability than in the non-DN group (13.67 ± 2.99) mm Hg and (16.35 ± 3.69) mm Hg, respectively. Conclusions: In patients with heart disease DN with equivalent glomerular filtration rate values, higher albumin to creatinine ratio and lipid profile disorders were substantially more common than in the non-diabetic renal disease category of patients. The mean daily diastolic pressure was significantly higher in the group of patients with DN than in the non-DN group ([124.50 ± 33.78] and [111.50 ± 11.5] mm Hg, P < 0.05), with significantly lower SBP variability than in the non-DN group (13.67 ± 2.99) mm Hg and (16.35 ± 3.69) mm Hg, respectively. In the lipid trend, DN patients have more apparent triglyceride level disorders than in the non-diabetic kidney damage category with equivalent GRF values.
Author(s) Details
Klitsunova Yuliia Aleksandrovna
Department of Family Medicine with the Courses of Dermatovenereology and Psychiatry, SI “Zaporizhzhya Medical Academy of Post-Graduate Education, Ministry of Health of Ukraine, Ukraine.
Ostapenko Andrii Alekseevich
Department of Laboratory Diagnostics and General Pathology, SI “Zaporizhzhya Medical Academy of Post-Graduate Education, Ministry of Health of Ukraine, Ukraine.
Ivahnenko Nataliia Timofeevna
Department of Family Medicine with the Courses of Dermatovenereology and Psychiatry, SI “Zaporizhzhya Medical Academy of Post-Graduate Education, Ministry of Health of Ukraine, Ukraine.
Kulbachuk Aleksandr Sergeevich
Department of Family Medicine with the Courses of Dermatovenereology and Psychiatry, SI “Zaporizhzhya Medical Academy of Post-Graduate Education, Ministry of Health of Ukraine, Ukraine.
Ivaschuk Viktoriia Aleksandrovna
Department of Family Medicine with the Courses of Dermatovenereology and Psychiatry, SI “Zaporizhzhya Medical Academy of Post-Graduate Education, Ministry of Health of Ukraine, Ukraine.
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