Monday, 1 September 2025

Splenogonadal Fusion: Pathogenesis, Diagnosis and Management | Chapter 3 | Medical Research and Its Applications Vol. 10

 

Splenogonadal fusion is an abnormal connection between the spleen and gonads. This rare entity can be easily confused with testicular tumors. It usually accompanies congenital malformations, such as cryptorchidism, making diagnosis more difficult. Herein, we report two rare cases of this challenging diagnosis. The first case involved a 5-year-old child admitted for management of bilateral testicular cryptorchidism complicated by an inguinal hernia on the left. Intraoperatively, we discover a globular left testis with two red ovoid formations of 4mm. There was no connection between the testis and the lower edge of the spleen. One of these formations was biopsied, showing normal splenic parenchyma and confirming the diagnosis of splenogonadal fusion. The second case was a 9-month-old infant followed for a disorder of sex differentiation, stage III of Prader with a 46, XY genotype. Diagnostic laparoscopy showed bilateral testicular cryptorchidism with intraabdominal testes. There was a left testicular nodule connected to the lower cryptorchidism edge of the spleen with a cord-like structure. A biopsy of the nodule showed normal splenic parenchyma. Bilateral orchidopexy was performed without removal of the left testicular nodule. Our two cases highlight the fact that surgeons must be aware of this entity to avoid unnecessary orchiectomy. In some cases, a biopsy may help with diagnosis.

 

 

Author(s) Details

Khouloud Ben Lazreg

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia.

Imen Helal

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Fatma Khanchel

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Aida Daieb

Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia and Pediatric Surgery Department, Habib Thameur Hospital, Tunis, Tunisia.

Sameh Tlili

Pediatric Surgery Department, Regional Hospital of Zaghouan, Zaghouan, Tunisia.

Sirine El Fekih

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Ehsen Ben Brahim

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Youssef Hellal

Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia and Pediatric Surgery Department, Habib Thameur Hospital, Tunis, Tunisia.

Raja Jouini

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Achraf Chadli Debbiche

Pathology Department, Habib Thameur Hospital, Tunis, Tunisia and Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

 

Please see the link:- https://doi.org/10.9734/bpi/mria/v10/1124

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