Relationship between HbA1c and Vascular Endothelial Growth Factor Serum Level in Diabetic Retinopathy Patients| Chapter 12 | Perspective of Recent Advances in Medical Research Vol. 3

 This study aims to decide the connection 'tween HbA1c level and vascular endothelial development determinant (VEGF) antitoxin levels in diabetic retinopathy (DR) victims. VEGF is a proangiogenic glycoprotein, that increases vascular permeability in DR. This is an examining cross-divided study of DR with type 2 diabetes subjects utilizing a valuable sipping method. The study people was gathered into non-proliferative DR (NPDR) and proliferative DR (PDR). HbA1c and VEGF antitoxin levels were evaluated by attractive the patient's unmodified blood. A total of 82 cases were contained, at which point the mean HbA1c levels were 8.17% ± 1.91%, and the middle VEGF levels were 85.78 ng/L (range 38.23-149.43 ng/L). A total of 23 consumed 35 NPDR sufferers were female (65.7%), while 29 from 47 PDR sufferers were male (61.7%). Approximately 61.7% of PDR subjects had diabetes for as well 10 age, while 62.9% of NPDR inmates had diabetes for inferior 10 age. The PDR group had a bigger mean HbAlc level than the NPDR group, but the distinctness was not statistically important (p =0.214). There was certainly sameness in middle VEGF levels 'tween two together groups. Spearman's study of equatings raise no equivalence betwixt HbA1 and VEGF levels in DR, two together in the NPDR and PDR groups (Correlation cooperative 0.183 and -0.022, individually). In subjects accompanying diabetic retinopathy, skilled was no statistically meaningful friendship middle from two points HbA1c and VEGF antitoxin levels. Poor glycemic control's belongings on the progress of VEGF were not showed in this place inspection. A tombstone of the asperity of DR grant permission not be the antitoxin level of VEGF.

Author(s) Details:

N. M. A. Surasmiati,
Department of Ophthalmology, Sanglah General Hospital, Udayana University, Denpasar, Bali, Indonesia.

M. P. Wijayati,
Department of Ophthalmology, Sanglah General Hospital, Udayana University, Denpasar, Bali, Indonesia.

I. A. A. Pramita,
Department of Ophthalmology, Sanglah General Hospital, Udayana University, Denpasar, Bali, Indonesia.

N. L. D. Pantjawati,
Ophthalmologist, Bali Mandara Eye Hospital, Indonesia.

A. Andayani,
Department of Ophthalmology, Sanglah General Hospital, Udayana University, Denpasar, Bali, Indonesia.

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