In this episode, we describe the results obtained from our two, currently published studies that aimed to demonstrate the appearance of Cx26 and its immunolocalization in informer cardiomyocytes, in differentiated (d)H9c2 cardiac rat containers and in extracellular vesicles from dH9c2 cell light in weight. Connexins (Cxs) are a family of membrane-traversing proteins, expressed easily intimidated and named according to their microscopic weight. They are famous to form gap junctions, sheath channels mediating container-cell communication, which play an essential part in the propagation of energetic activity in the heart. Cx26 has existed described in any of tissues and its mutations are frequently guide deafness and skin diseases. Only currently, Cx26 has been described in the essence, at level of vessels and cardiomyocytes, and allure localization is scattered all over the container at the level of different subcellular compartments apart from at the intercalated discs as is the case for the other cardiac Cxs. The working characterization of Cx26 in cardiomyocytes debris poorly understood due to this current discovery in the courage tissues. However, the peculiar localization at the level of extracellular vesicles suggested a particular role for cardiac Cx26 in bury-cellular communication in a break junction liberated manner.
Author(s) Details:
Alessandra Falleni,
Department
of Clinical and Experimental Medicine, University of Pisa, Italy.
Antonella
Cecchettini,
Department
of Clinical and Experimental Medicine, University of Pisa, Italy.
Margherita Bernardeschi,
Italian Institute of Technology, Center for Materials Interfaces,
Smart Bio-Interfaces, Pontedera, Italy.
Stefania Moscato,
Department of Clinical and Experimental Medicine, University of
Pisa, Italy.
Letizia
Mattii,
Department
of Clinical and Experimental Medicine, University of Pisa, Italy.
Please see the link here: https://stm.bookpi.org/CODH-V7/article/view/9079
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