Insulin-like growth factor-I is a key molecule that has generated a lot of interest in gerontology (IGF-I). For the past ten years, the relationship between IGF-I and replacement treatment has been the focus of numerous studies. It is believed that the aging-related loss in physical functions is accompanied by a fall in IGF-I levels. Age-related declines in IGF-I levels are observed in adults. Age-related changes in growth hormone (GH) and insulin-like growth factor I (IGF-I) levels may result in increased body fat, decreased muscle strength, decreased bone mass, decreased lean body mass, and eventually, a number of age-related disorders. The quality of life may suffer as a result of this fall in IGF-I, which may also lower total bodily performance. In order to acquire a sense of the therapeutic step and provide perspective on a potential IGF-I replacement therapy in healthy older adults, we examined the preceding history of the relevant articles in the current review. This review will go into greater detail regarding the benefits and drawbacks of the IGF-I system's influence on the aged organ systems. Additionally, we want to talk about IGF-general I's functional characteristics, the implications of using it as a substitute in healthy older people to raise their standards of physical and mental well-being, and its drawbacks and contemporary perceptions.
Author(s) Details:
Hakkı Dalçık,
Department of Anatomy, School of Medicine, Istanbul Aydin University, Kucukcekmece, Istanbul, Turkey.
Cannur Dalçık,
Department of Anatomy, School of Medicine, Istanbul Aydin University, Kucukcekmece, Istanbul, Turkey.
Please see the link here: https://stm.bookpi.org/CIMMS-V4/article/view/8396
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