Synthesis and Antitumor Activity of Tetrahydroisoquinoline Derivatives | Chapter 7 | Current Topics on Chemistry and Biochemistry Vol. 4

 

 When 1-methylpiperidin-4-one was converted to the corresponding -unsaturated ketones, the reaction time should not exceed 4 hours. The DBU was selected as the best strong base for the reaction of the -unsaturated ketones and malononitrile. Then, using a moderate synthetic method, fifteen new tetrahydroisoquinoline compounds were produced. The 1H NMR, 13C NMR, and mass spectra were used to confirm the structures of all the compounds. Four human tumour cell lines, including human colon cancer (HCT116), non-small cell lung cancer (H1975), lung adenocarcinoma (A549), and human pancreatic cancer, were used to assess the anticancer effects of these compounds (BxPC-3). Compounds 4i and 4j, which had GI values of 59.1 and 63.0 percent, respectively, demonstrated significant growth inhibitory activity against the whole subpanel tumour under examination.

Author(s) Details:

Xue-Ting Feng,
College of Pharmacy, Southwest Minzu University, Chengdu, 610041, China.

Dao-Cai Wang,
College of Biologic Science and Technology, Hubei Minzu University, Enshi, 445000, China.

Hang Song,
School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.

Shun Yao,
School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.

Please see the link here: https://stm.bookpi.org/CTCB-V4/article/view/7810