Drug Delivery Control Using Iron Oxide Nanoparticles in Three-Dimensional Magnetic Resonance Imaging: A Descriptive Approach | Chapter 1 | Recent Trends in Chemical and Material Sciences Vol. 9

This chapter explains the use of iron oxide nanoparticles in 3D MRI as a drug distribution control mechanism. It describes how to evaluate the effectiveness of medicine distribution by using MRI scans to identify and distinguish the cluster intensity created by Iron oxide nanoparticles (IO-NPs). IO-NPs connected to macrophages were injected into the infected mouse's calf eye. Due to the low resolution of MRI and the tiny size of the IO-NPs, the situation was challenging. IO-NPs act as a marker in MRI and their high intensity allows us to monitor the macrophages' development. Using an image processing method, the number and location of IO-NPs that were spreading into the infected mouse leg were estimated. The region of interest was selected using a fuzzy Clustering approach (ROI). IO-NPs were found and extracted from MRI images using a 3D model of the femoral region. The findings collected demonstrate that the suggested technique is successful in enhancing the management of targeted medication delivery. It supports the improvement of therapy and creates a promising new line of inquiry for nanomedicine applications.

Author(s) Details:

Mohammed Almijalli,

Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Khalid Alhussaini,

Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Adham Aleid,

Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Abdullatif Alwasel,

Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Ali Saad,

Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Please see the link here: https://stm.bookpi.org/RTCAMS-V9/article/view/7374