Wednesday, 6 July 2022

Analysis of High-Resolution Computed Tomography Phenotypes and Pulmonary Function in Chronic Obstructive Pulmonary Disease | Chapter 8 | Current Practice in Medical Science Vol. 2

Introduction: Using high-resolution computed tomography (HRCT), many aspects of chronic obstructive pulmonary disease (COPD) may be diagnosed. FEV1) was seen with lower lobe and overall average MLD whereas a weak linear association of post-FEV1 was observed with (HRCT). This research aimed to evaluate COPD patients' HRCT features.

Materials and Methods: Of the 50 patients with COPD who satisfied the GOLD guidelines 2014 criteria for inclusion based on spirometry, 35 had an HRCT. The Philips lung densitometry computer application was used to calculate densities using these restrictions (-800/-1, 024 Hounsfield unit [HU]) after densitometry data were verified using phantoms. In order to quantify the attenuation as mean lung density (MLD) of the lower and upper lobes, we first designated the region of interest using a free-hand drawing, established restrictions (in HUs), and then utilised a computer programme.

Results: There was a significant correlation between the smoking index and the anterior-posterior tracheal diameter (P = 0.036). The tracheal index dropped with increasing disease severity, which was statistically significant (P = 0.037). Pre-forced expiratory volume in the first second (both coronal (P = 0.042) and sagittal (P = 0.001) lower lobes MLD) showed a weak linear connection. Additionally, there was a linear connection between sagittal lower lobe MLD and pre (P = 0.050) and post (P = 0.024) FEV1/forced vital capacity.

In conclusion, HRCT could be a helpful addition to the total COPD examination.

Author(s) Details:

Ravi Bhaskar,
Department of Pulmonary Medicine, Career Institute of Medical Sciences, Lucknow (UP), India.

Seema Singh,
Department of Respiratory Medicine, King Georges Medical University, Lucknow (UP), India.

Pooja Singh,
Department of Pulmonary Medicine, Career Institute of Medical Sciences, Lucknow (UP), India.

Sandeep K. Singh,
Govt. Pharmacy College, BRD Medical College Campus, Gorakhpur, UP, India.

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