This study adds crucial new insights and avenues to understanding and investigating the thermogenic effects of diet and diet-induced thermogenesis, as well as their potential contributions to energy balancing mechanisms. Diet-induced thermogenesis has been proposed to account for up to 15% of the caloric content of a meal and to decline with age and obesity. Genetically obese mice have been demonstrated to have impaired thermic responses to diet and environment, which may explain for their better caloric efficiency and contribute to their proclivity to become obesity. The purpose of this study was to see how thermic responses to diet and environment changed in obese rats of different ages. Resting oxygen consumption declined with age, and thermic responses in obese rats were lower than predicted as compared to lean rats, indicating deficits in both sympathetically and non-sympathetically mediated contributions to the process of non-shivering thermogenesis.
Author(S) Details
Orien L. Tulp
University of Science Arts and Technology, Montserrat, British West Indies, USA.
Susan P. De Bolt
College of Medicine, University of Science Arts and Technology, Montserrat, BWI, USA.
Aftab R. Awan
University of Health and Humanities, Virgin Islands, BWI, USA and Cambridge University, Cambridge UK.
George P. Einstein
College of Medicine, University of Science Arts and Technology, Montserrat, BWI, USA and University of Health and Humanities, Virgin Islands, BWI, USA and Department of Experimental Medicine, Einstein Medical Institute, USA.
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