This work produced 3-amino-2-methyl-quinazolin-4-(3H)-one (1) by reacting N-acetyl anthranilic acid with acetic anhydride and then treating the combination with hydrazine hydrate in pyridine. When compound 1 is reacted with chloro acetyl chloride, it produces 3-chloroethanoylamino-2-methyl-quinazolin-4-(3H)-one(2). The final compounds 4a-g were produced by reacting the substituted derivative 2 with aliphatic and aromatic secondary amines. The structural assignment of this chemical 4a-g was determined using elemental analysis, IR, and 1H NMR data. The compounds were evaluated in vitro for growth inhibitory activity and the minimal inhibitory concentration was determined. concentrations of inhibitors against diverse bacterial and fungal strains Antibacterial activity is highest in compounds 4a, 4b, 4e, and 4g, whereas antifungal activity is highest in compounds 4a, 4b, 4d, and 4e.
Author(s) Details:
G. S. Chhabra,
Indore Institute of Pharmacy, Indore( M.P), India.
Ravi Tiwari,
School of Pharmacy and Technology Management, SVKM's NMiMS University, Shirpur
Campus, Babulde, Bank of Tapi River, Mumbai-Agra Road, Shirpur-425 405, India.
Please see the link here: https://stm.bookpi.org/NICB-V7/article/view/5926
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