Rifamycin SV Intrasiniovally Injected in Arthritides Patients Showed Anti-Synovitis Activity and Some Features of the Disease Modifying Drugs: A Clinical Approach | Chapter 1 | Recent Developments in Medicine and Medical Research Vol. 14

 The outcomes of polyintrasynovial infiltration with Rifamycin SV in 658 individuals with various types of arthritides were studied retrospectively. The goal was to see if, in addition to curing synovitis, this treatment may also cause the remission of extrarticular disease symptoms.

Methods: The patients were separated into groups based on their treatment schedules:

-The arthritides group (374) in which patients were infiltrated in only one large joint with the goal of curing each synovitis case;
-those (189) who had their therapy extended from a single to a weekly infiltration of three or four large joints;
-a group of 95 individuals who had only their minor joints treated.

Every one of the 1,364 joints (727 large and 637 small) was infiltrated once a week for ten weeks, and all patients were observed for three years.

Individual synovitis was found to have a strong relationship with the kind of arthritides, the existence of radiological damage, and joint dimension. Extraarticular symptoms in psoriatic arthropathy were remitted in patients who had three or four joints infiltrated weekly, and clinical improvement and normalisation of inflammatory markers were seen in numerous rheumatoid arthritis patients. These alterations take a long time to manifest, often months after the infiltrations have ended.

Conclusions: The anti-proliferative and cytolytic activities of Rifamycin SV were linked to the result of synovitis. Remission of extrarticular arthritides should be maintained by complicated immune systems that Rifamycin SV may have only indirectly stimulated when it was absorbed through the intrasynovial route. The therapeutic effects of intrasynovial Rifamycin SV developed slowly during and, in most cases, after the infiltrations were completed.

Author(S) Details

Caruso Innocenzo
Past Chief Rheumatology Unit, L. Sacco Hospital Milano Italy Corso Italia 11, 20122 Milano, Italy.

Cazzola Marco
Rheabilitation Depertment, Saronno Hospital Varese, Italy.

Santandrea Salvatore
Rheumatology UOC, L.Sacco Hospital Milano, Italy.

Montrone Franco
Associazione Italiana Contro l’Artrite (AICA) Milano Italy.

Caruso Enzo Massimo
Orthopedic Unit, IST. Clinico San Siro, Milan, Italy.

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