Recent Study on Vitreomacular Interphase Disorders in Eyes with Proliferative Sickle Cell Retinopathy | Chapter 8 | Highlights on Medicine and Medical Research Vol. 3

Purpose: A set of characteristic retina complications that occur in patients with sickle cell haemoglobinopathy is sickle cell retinopathy (SCR). Based on optical coherence tomography results, to identify the type of vitreomacula interface disorders (VID) seen in eyes with proliferative sickle cell retinopathy and to assess their effect on visual acuity. Methods and Patients: It was a retrospective case study for observation. To classify all PSR cases with Fourier-domain OCT imaging showing VIDs at a single academic private-practice office location from January 1, 2015 to July 30, 2018, clinical records and imaging records were checked. Vitreomacula Adhesions, Vitreomacula Traction, Lamellar Macula Hole, Full Thickness Macula Hole, Epiretina membranes and Macula Pseudohole were categorised as defined VIDs. Results: Out of a total of 98 eyes out of 78 examined PSR patients, only 12 eyes had VIDs, representing 12.2% of PSR patients. There were 3 (25 percent) males and 9 (75 percent) females aged between 32 and 64 years, with a mean age of 45.42 years [SD 10.27], affected by 9 (75 percent) right eyes. Their genotype was SC in 9(75 per cent) patients and 3(25 per cent) with genotype SS. In 6(50 percent) eyes, PSR was at stage 3, while the remaining 6(eyes) were at step 4. Epiretine membranes (ERM) were the most prevalent VID seen in 7(58.3 percent) eyes, Lamella Macula Holes were associated with 2(16.6 percent) ERM eyes, and a pseudohole was associated with ERM in 1(8.3 percent). In 3(25 percent) eyes, VMAs were seen and FTMHs were seen in 2 (16.6 percent) eyes. ERMs were therefore seen in 7.1 percent of the 98 PSR eyes that were considered (7 eyes). Conclusion: The most prominent vitreomacular interphase disorders seen in our eye series with proliferative sickle cell retinopathy are epiretina membranes with or without macular holes. They have been linked to mild to moderate visual acuity deficiency.

Author (s) Details

Olufemi Oderinlo
Eye Foundation Hospital, 27 Isaac John Street, GRA Ikeja, Lagos, Nigeria.

Adekunle Hassan
Eye Foundation Hospital, 27 Isaac John Street, GRA Ikeja, Lagos, Nigeria.

Ogugua Okonkwo
Eye Foundation Hospital, 27 Isaac John Street, GRA Ikeja, Lagos, Nigeria.

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