Stereotactic radiosurgery (SRS) has been widely used not only for intact brain metastases but also late after surgery for the postoperative cavity of metastases, due to the benefits of SRS in preserving neurocognitive functions, maintaining local control and prescribing treatment in a short time frame. Randomized trials have proven the safety and efficacy of cavity SRS compared to observation. There has been a revolution in clinical approach for patients with limited intact brain metastases to treat with SRS only and omit WBRT, as WBRT offers no survival advantage compared to SRS and frequent monitoring with brain MRIs for early rescue upon failure. Recent implementation of PO-SRS applications to the resected BMs treatment algorithm has reputably enhanced local control at the surgical resection bed compared to observation or WBRT Similarly, there is a growing reputation for postoperative cavity SRS for brain metastases. In this review, we summarize the evidence for evidence-based optimization in the postoperative setting of brain metastases that have been surgically removed.
Author (s) DetailsYasemin Bolukbasi
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Ugur Selek
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Duygu Sezen
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Nulifer Kilic Durankus
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
Eyub Yasar Akdemir
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
Sukran Senyurek
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
Ahmet Kucuk
Mersin City Education and Research Hospital, Radiation Oncology Clinics, Mersin, Turkey.
Berrin Pehlivan
Department of Radiation Oncology, Bahcesehir University, Istanbul, Turkey.
Erkan Topkan
Department of Radiation Oncology, Medical Faculty, Baskent University, Adana, Turkey.
View Book :- https://stm.bookpi.org/HMMR-V2/issue/view/20
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