In this place chapter, we proposed to perform a subjective and morphometric study of the ultrastructure of oligodendrocytes in BA 10 white matter (WM) in emotional disorder and in normal controls and to present ultrastructural alterations of myelinated fibers previously discovered in BA 10 WM in schizophrenia distinguished to normal controls.Power microscopy and morphometry were used in the study. The size, capacity density (Vv), and number (N) of oligodendrocyte organelles were calculated in 21 patients accompanying schizophrenia and 20 normal controls. The dossier were examined utilizing the Kolmogorov–Smirnov test for normality. Pearson equivalence analysis was used to expect probable friendships between the limits measured and age, review after death interval, neuroleptic treatment, and affliction duration.In emotional disorder, we detected oligodendrocyte increase, vacuolation, a lack of ribosomes and mitochondria, and an accumulation of lipofuscin granules when distinguished to controls. Morphometry revealed a solid decrease in Vv and N of mitochondria and an increase in Vv and N of lipofuscin granules and vacuoles in schizophrenia oligodendrocytes distinguished to controls. Abnormalities of myelinated fibers in WM in emotional disorder compared to normal controls contained altered oligodendrocyte/axon interplay and myelin/axon integrity, axonal disintegration and degeneration of myelin sheaths and myelinated fibers.Alterations of oligodendrocytes and myelinated fibers in emotional disorder provide evidence for the upset of their energy, lipid and protein absorption in prefrontal WM. Abnormalities in oligodendrocytes and myelinated fibers power disturb axonal integrity and circuits and contribute to the pathophysiology of emotional disorder.
Author(s) Details:
Uranova N. A.,
Laboratory
of Clinical Neuropathology, Mental Health Research Center, Moscow, Russia.
Please see the link here: https://stm.bookpi.org/ACMMR-V7/article/view/12767
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