Epigenetic Aberrations in Mental Disorders are Linked to Diet and Gut Microbiome Alterations | Chapter 12 | Advanced Concepts in Medicine and Medical Research Vol. 10

Food and metabolism modify epigenetic codes to a degree histone methylation or acetylation and DNA methylation intervened by bioactive nutrients and gut microbial factors by way of influencing the gut–brain hinge, which adjust neuronal activity and behavior.This stage discusses epigenetic aberrations had connection with diet and gut microbiome alterations in major psychiatric afflictions such as schizophrenia, manic-depressive illness, and autism. Here, this study first argued modifications to the structure and makeup of gut microbiome and their duty in brain functional changes in weighty mental sicknesses. Afterwards, potential interactions with maternal diet, environmental determinants, nutrition, and gastrointestinal microbiome, and their acts in the pathogenesis of mental illnesses by way of epigenetic changes were discussed. This study still provided an overview of the friendship between the gut microbiome, oxidative stress, and inflammation moving epigenetic mechanisms. Furthermore, this chapter presented latent mechanisms which arbitrate the influence of gut microbiome, probiotics, and psychiatric drugs on insane health via microbiome-epigenetic modifications. Completely, it was concluded that disease pathogenesis is connected to changes in the microbiome structure/arrangement by perturbing the microbiome–gut-brain axle functions. Further research is needed to obtain better insights on unusually transmitted microbiomes on infant well-being, to mitigate the inceptions of neurodevelopmental diseases at early ages.

Author(s) Details:

Shabnam Nohesara,
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.

Hamid Mostafavi Abdolmaleky,
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA and Department of Surgery, Nutrition / Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boson, MA, 02215, USA.

Sam Thiagalingam,
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA and Department of Pathology & Laboratory Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Please see the link here: https://stm.bookpi.org/ACMMR-V10/article/view/12837