Application of Apri and Fib_4 Biomarkers in Stratifying the Degree of Hepatic Involvement in HIV-HCV Coinfection | Chapter 8 | Advanced Concepts in Medicine and Medical Research Vol. 10

Acquired immune deficiency syndrome/Hepatitis C co-infections are accepted and represent main public health problems as it influences between 2 and 3 heap people general This study developed located onnon-invasive tests utilizing biomarkers was conducted on victims co-infected with Immunological disorder and HCV. This chapter focuses on judging the degree of hepatic connection using APRI and FIB 4 scores in liver damage in those co-polluted with Disease given through sexual relations/HCV in Côte d'Ivoire. This study qualitative pattern of semi-directive interviewing was used to interview that was attended from September 2019 to November 2019Serological tests were performed to resolve the data. APRI and FIB 4 scores were deliberate for each patient from organic data acquired by COBAS C311 (Roche Hitachi, Japan). Mathematical analyses were performed utilizing GraphPad and MED-CALC software.The study complicated 30 patients (husbands) of middle age (25 - 52 age), with limits ranging from 0.67 to 8 for APRI and 0.201 to 22 for FIB 4. A predicting APRI and FIB4 score of significant hepatic fibrosis was observed in 23% of victims; however, 46% and 54% of sufferers for the APRI and FIB 4 score, respectively, would not have meaningful fibrosis. An APRI and FIB4 score not included in the categorization limits of the type of fibrosis hepatitis was observed in 31% and 23% of sufferers, respectively. The findings concerning this study revealed that APRI and FIB-4 good prejudicial capacity in the disease of liver cirrhosis in people endure hepatitis C in accordance with additional research.The study showed that APRI or FIB 4 score illustrated good discriminatory capacity to categorize patients into the various stages of liver fibrosis, as about 70 and 77%, respectively, of the patient state could be top-secret in the stages of hepatitis C fibrosis based on the understanding of their criteria.

Author(s) Details:

Serge Kouakou Kouassi,
Biology and Health Laboratory, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire.

Doumbia Moussa,
Department of Bacteriology-Virology, Bacterial and Viral Serology Unit, Institut Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire.

Alexis Bahi,
Department of Medical and Fundamental Biochemistry, Institut Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire.

Carole N’Guessan Djaman Obouayeba,
Biology and Health Laboratory, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire.

Françis Adou Yapo,
Biology and Health Laboratory, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire.

Joseph Allico Djaman,
Biology and Health Laboratory, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire and Department of Medical and Fundamental Biochemistry, Institut Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire.

Please see the link here: https://stm.bookpi.org/ACMMR-V10/article/view/12822