The current experiment was devised to develop and endorse a simple RP-HPLC methods for determining Cilnidipine. Cilnidipine was quantified utilizing UV spectroscopy. Action separation of Cilnidipine was realized by using a C18 pillar. Mobile phase blend of methanol: water (90:10 v/v) was pressure at the flow of 1 ml/min. Detection At 241 nm, detection was completed activity. In accordance with the International Conference on Harmonization's (ICH) Q2R1 recommendations, confirmation parameters were determined. With a parametric value (r2) of 0.999, the uniformity curve for cilnidipine was linear over the range of 2–10 mg/ml. The plan was noticed to be correct (101.66% recovery), exact (intraday, 1.65 and inter epoch, 1.38) and robust (% RSD was premeditated to be 0.66, 0.58 and 0.81 for alternative in mobile phase arrangement, wave length and flow speed respectively) for the reasoning of Cilnidipine. The developed system has successfully achieved all validation tests and can be used to estimate the attendance of cilnidipine in both drug formulations and bulk.
Author(s) Details:
Biswajit Samantaray,
School
of Pharmacy and Life Sciences, Centurion University of Technology and
Management, Odisha, India.
Satish
Kanhar,
School
of Pharmacy and Life Sciences, Centurion University of Technology and
Management, Odisha, India.
Ashirbad Nanda,
School of Pharmacy and Life Sciences, Centurion University of
Technology and Management, Odisha, India.
Please see the link here: https://stm.bookpi.org/COPS-V3/article/view/9112
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