This study sought to determine how khat habituation affected the psychomotor behaviour of mice as well as how khat removal affected the consequences of khat habituation.
18 mature mice weighing 20–30 g were used in this study. Three groups of the animals were created, one of which served as a control group. After an overnight fast, 2 g/kg of khat was administered with meals to encourage khat habit formation. After a week, both khat-containing and non-khat-containing products were available to the test animals, with most of them favouring the khat-containing diets. Animals that liked khat-containing food were considered to have developed chronic khat habituation and were fed khat at a dosage of 2g/kg/day for two months. Animals that did not prefer khat-containing food were left out of the trial and were thought to be resistant to khat habituation. To cause khat withdrawal, animals were fed for 14 days without any khat. Animal locomotor movements were monitored and rated using a behaviour scale in order to assess how khat habituation affects locomotor activity and how khat withdrawal affects the reversal of khat effects. Stereotypical psychomotor behaviour significantly increased in khat-habituated animals and peaked 15 to 30 minutes after khat usage. The psychomotor behaviour of mice restored to normal after a 14-day khat abstinence. The psychomotor behaviour of mice is markedly enhanced by chronic khat habituation, although this effect is just transient and may be reversed if the habit is interrupted.
Author (s) Details:
Hussein O. Al-Kadi,
Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, Sana’a University, Yemen.
Shawqi H. Al-Awdi,
Department of Pharmacy, Faculty of Medicine and Health Sciences, Thamar University, Yemen.
Mohanad M. Shehab,
Department of Clinical Pharmacology, Faculty of Medicine, Benha University, Egypt.
Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7522
No comments:
Post a Comment