Febrile Neutropenia: A Review | Chapter 4 | Current Practice in Medical Science Vol. 2

An absolute neutrophil count of less than 500/mm3 and an oral temperature of greater than 38.3°C are indicators of febrile neutropenia. Traditional cytotoxic chemotherapy treatments' most frequent dose-limiting hazard, which has also been seen with targeted and immunological therapies, is bone marrow suppression. The majority of infections are caused by bacteria, but they can also be caused by viruses or fungi. Gram-positive bacteria infections including those caused by Staphylococcus, Streptococcus, and Enterococcus species are typical bacterial pathogens. Infectious agents that are also drug-resistant have been found include Klebsiella species, Pseudomonas aeruginosa, Acinetobacter species, Stenotrophomonas maltophilia, and Escherichia coli. One occurrence of drug-induced neutropenia occurs out of every million people per year. Twenty percent of patients with severe neutropenia and about fifty percent of those with febrile neutropenia will get bacteremia. The MASCC was developed to evaluate the possibility of severe consequences in neutropenic fever patients. The highest MAASC index score is 26. Patients who score more than 21 are categorised as low risk, whereas those who score less than 21 are high risk. The primary factor for febrile neutropenia is bone marrow suppression brought on by various cancer therapies. The study's major goal is to make recommendations for prompt treatment of febrile neutropenia in order to improve patient survival rates.

Author(s) Details:

Sunder Singh,

Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.

Ashish Kumar Malik,

Department of Psychiatry, N.C. Medical College and Hospital, Israna, Panipat, Haryana, India.

Rakesh Dhankhar,

Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.

Kiran Dahiya,

Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.

Deepika Dalal,

Department of Biochemistry, N.C. Medical College and Hospital, Israna, Panipat, Haryana, India.

Please see the link here: https://stm.bookpi.org/CPMS-V2/article/view/7343