This study's goal was to use the solid dispersion (SD) approach to increase the solubility and subsequent antibacterial activity of cefuroxime axetil (CA), a broad-spectrum, second-generation cephalosporin that is beta-lactamase stable. A solvent evaporation procedure was used to create CA loaded SDs (CSDs) with different concentrations of microcrystalline cellulose (MCC) acting as a carrier. In-vitro dissolving studies, temperature analysis (DSC), crystallinity (PXRD), interactions (FTIR), and morphology were used to characterise CSDs (SEM). CSD-2 exhibited the greatest solubility rate among the formulations, 2.59 times stronger than pure CA, with a drug-carrier (CA: MCC) ratio of 1:3. Investigations using DSC, PXRD, FTIR, and SEM proved that the drug's change from crystalline to amorphous form during the creation of SDs was the cause of the faster dissolving rate. When compared to pure CA, the relative zone of inhibition (RZOI) of CSD-2 against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) was 1.94 and 6.75 times greater, respectively. The most successful optimised formulation in terms of increased dissolving rate and antibacterial activity has been identified as CSD-2. Therefore, it could be a potential substitute for conventional CA dose formulations. More investigation is required to assess its pharmacokinetic characteristics, in vivo antibacterial effectiveness, and safety before recommending it as a new formulation.
Moushumi Tabassoom Salam,
Laboratory of Pharmaceutics, Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi-6205, Bangladesh.
Ashim Kumar,
Laboratory of Pharmaceutics, Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi-6205, Bangladesh.
Ranjan Kumar Barman,
Laboratory of Pharmaceutics, Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi-6205, Bangladesh.
Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7505
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