Anti-Retroviral Regimen Change & Subsequent Patient–Related Outcomes in South Africa | Chapter 6 | Current Practice in Medical Science Vol. 2

The purpose of the study was to discover variables that impact antiretroviral treatment (ART) regimen modification and to evaluate patient outcomes post regimen change. At a Provincial Hospital ARV Clinic in KwaZulu-Natal, from January 2008 to December 2012, a retrospective chart analysis of 269 HIV-infected non-pregnant patients (age >18 years) who underwent an antiretroviral (ARV) regimen change and were followed up for roughly one year since initiation was conducted. Findings showed that 200 of the 269 cases involved women (75 percent). Most of the patients were in the 30 to 44 age range (57.6 percent). Only five of the people were infected with TB (2 percent). Stavudine (D4T)/ lamivudine (3TC)/ efavirenz (EFV) was the first-line ART regimen that was altered the most frequently (n = 111). (41 percent ). Tenofovir (TDF)/3TC/EFV was the most often changed medication for patients (n = 89). (33 percent ). The most often used medication alternative was stavudine (35.5 percent ). ADRs with lipodystrophy were more prevalent (56.8 percent ). ADR was the reason for changing the ART regimen in 175 patients (65%), whereas treatment failure (TF) was the reason in 94 individuals (35 percent ). After changing the regimen, immunological success (CD4 counts) was seen (374.21 243.16 vs. 456.09 250.07, CI: 0.95, p 0.001). After the regimen was changed, undetectable viral levels were discovered in 172/205 (83.9%) patients. According to the findings of this study, adverse drug reactions (ADRs) were the primary reason why antiretroviral regimens were changed. Lipodystrophy was the most frequent adverse effect of stavudine, the medicine that was most frequently replaced. After changing the regimen, progress was seen in the areas of immunology and virology.

Author(s) Details:

Vereesha Soorju,

Madadeni Hospital, School of Health Sciences, University of KwaZulu - Natal, South Africa.

Panjasaram Naidoo,

Madadeni Hospital, School of Health Sciences, University of KwaZulu - Natal, South Africa.

Please see the link here: https://stm.bookpi.org/CPMS-V2/article/view/7345