The goal of this study was to look for age-related changes in conventional sperm parameters and sperm DNA damage in healthy nonsmoking men who were exposed to traffic pollution at work. Semen samples from 150 Prague and 54 Ostrava City police officers ranging in age from 21 to 63 years were tested for conventional semen characteristics, sperm DNA fragmentation, and high DNA stainability. For both Prague (r = 0.359, p 0.001) and Ostrava (r = 0.392, p = 0.003) police officers, there was a strong positive association between age and percent DFI. Age and sperm vitality (r = -0.247, p = 0.001), percent acrosome-intact sperm (r = -0.202, p = 0.013), and percent normal sperm heads (r = -0.204, p = 0.012) were found to have negative relationships in Prague. High DNA stainability (percent HDS) vs. age was found to have a weak but significant negative connection (r = -0.161, p = 0.050). The mean percent DFI values at the ages of 23-30, 31-40, 41-50, and 51-63 years were 12.77.18, 14.77.42, 19.611.25, and 34.215.08, respectively. Only a negative association was identified between age and the percentage of morphologically normal sperm (r = -0.374, p = 0.005), percent normal sperm heads (r = -0.310, p = 0.022), and percent HDS (r = -0.332, p = 0.014) in Ostrava. Sperm viability was marginal (r = -0.256, p = 0.062). In Ostrava, no significant link was found between male age and the other studied sperm quality criteria. Our findings reveal a substantial link between men's age and sperm DNA fragmentation in an occupational group exposed to high levels of traffic-related air pollution in a large city centre.
Author(S) Details
Jiri Rubes
Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Jaroslav Sipek
Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Vera Kopecka
Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Petra Musilova
Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Miluse Vozdova
Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology-Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Jan Topinka
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine, Czech Academy of Science, Videnska 1083, 142 20 Prague 4, Czech Republic.
Anna Pastorkova
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine, Czech Academy of Science, Videnska 1083, 142 20 Prague 4, Czech Republic.
Vlasta Svecova
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine, Czech Academy of Science, Videnska 1083, 142 20 Prague 4, Czech Republic.
Radim J. Sram
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine, Czech Academy of Science, Videnska 1083, 142 20 Prague 4, Czech Republic.
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