Hepatitis E Virus (HEV) is a single-stranded RNA virus. The
phosphorylation patterns in HEV ORF4 remain unelucidated. As phosphorylation
regulates the activity in proteins, thus the identification of phosphorylation
sites (P-sites) in HEV ORF4 protein is much needed. Herein, we report the
prediction of P-sites in ORF4 proteins by employing a web-based server with
improved accuracy. Comparative analysis revealed the prevalence of P-sites
within intrinsically disordered regions of ORF4. It was observed that the
composition of amino acid residues surrounding P-sites was enriched in
disordered-promoting residues in ORF4. The occurrence of P-sites within the
identified protein’s disordered regions in conjunction with subsequent
enrichment in disordered residues around P-sites suggests a tight
interconnection between protein phosphorylation and disorder. The presented
study is aimed to provide insights regarding the role of disorder in protein
phosphorylation.
Author(s) Details
Zoya Shafat
Centre for Interdisciplinary Research in Basic Sciences,
Jamia Millia Islamia, New Delhi 110025, India.
Please see the link:- https://doi.org/10.9734/bpi/mono/978-81-976007-3-9/CH4
