Prodrugs are bioreversible compounds of pharmacologically alive substances that must meet with an in vivo enzymatic and/or synthetic change to release the parent drug and produce the intended effect. The drug's pharmacological project is hidden in a prodrug and renewed via something which incites activity-mediated bioconversion. The exercise of the prodrug strategy allows the manipulation of a drug's solubility, synthetic stability, reduce presystemic absorption, andtargeting towards specific sites. Specific type of prodrugs are ester prodrugs, that are most commonly able by combining drugs accompanying carboxylic acid group and drugs containing alcoholic or phenolic groups indifferent esterification conditions. Skilled are literatures that extensively examine NSAID-ester prodrugs. Esterification of NSAIDs masks the free carboxylic acid group, reducing gastrointestinal aftereffects. The sustained release can disclose the reduced reactions. Ester prodrugs have the potential to be exploited for the purpose of modifying or changing drug characteristics, accordingly holding promise for future requests.
Author(s) Details:
ManojKumar Sahoo,
Department
of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Nidhi
Agrawal,
Department
of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Meenakshi Jaiswal,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur
(C.G.) - 495009, India.
S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur
(C.G.) - 495009, India.
Please see the link here: https://stm.bookpi.org/ACPR-V3/article/view/12713
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