Simvastatin is individual of the well-known statins that is a HMG-COA reductase inhibitor. Metformin hydrochloride is a well- known spoken antihyperglycemic drug. The present work has created and validated a precise and correct reverse phase liquid chromatographic means for the simultaneous estimation of simvastatin and metformin. This is cause the reversed step HPLC method is ultimate suitable for assessing two together ingredients happening at about the same time. The method was created utilizing a Jasco Auto polltaker HPLC with 50mM Sodium Dihydrogen Phosphate Monohydrate at pH 3.0 and Acetonitrile (30:70 v/v). UV-visible detectors were secondhand for the analysis, and 235 nm was used to monitor the eluents. Simvastatin and metformin were proved to have retention opportunities of 7.650 and 2.858 minutes, respectively. The approach was corroborated in terms of time, robustness, precision, and veracity. The planned method for the simultaneous quantitative perseverance was implemented efficiently.
Author(s) Details:
R. Varade,
Pacific
University, Udaipur, Rajasthan, 313024, India.
H.
Mishra,
K.
J. Somaiya Institute of Engineering and Information Technology, Mumbai, MH,
400022, India.
Please see the link here: https://stm.bookpi.org/ACPR-V3/article/view/12703
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