The Role of Interleukin-12 Cytokines in Periodontitis Pathogenesis | Chapter 4 | Advanced Concepts in Medicine and Medical Research Vol. 3

 Every instigative process is fueled by a cascade of instigative mediators. Periodontitis is a common angering condition that affects people general. The causative microorganisms release chemicals that mobilize the innate invulnerable system, causing it to hide proinflammatory cytokines, which aid in further progress. This activates the acquired invulnerable system, making further damage to the periodontal attachment apparatus. The cytokines freed by the invulnerable response can cause supplementary damage to the periodontal ligaments, gingiva, and alveolar bone as the invulnerable response advances. Cytokines of various sorts have existed associated with periodontitis.Interleukin 12 (IL-12) is a strong harmful impetus in the pathophysiology of many inflammatory afflictions. Increased levels of IL-12 in blood and gingival crevicular fluid have existed linked to the severity of periodontitis. However, the distinguishing role of IL-12 in periodontitis debris uncertain. This member will focus on IL-12 cytokines as instigative mediators in periodontal disease. It describes the pathophysiology of periodontitis and the key instigative mediators.

Author(s) Details:

Nada Tawfig Hashim,
Rak College of Dental Science, Rak Medical Health Sciences University, Ras-Al-Khaimah, UAE.

Mohammed Mustahsen Rehman,
Rak College of Dental Science, Rak Medical Health Sciences University, Ras-Al-Khaimah, UAE.

Bakri Gobara Gismalla,
Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.

Please see the link here: https://stm.bookpi.org/ACMMR-V3/article/view/12366