Plant Derived Medications for Fibromyalgia: A Comparative Study | Chapter 4 | Advanced Concepts in Pharmaceutical Research Vol. 3

 This episode discuss about attainable effect of Passiflora edulis Sims on reserpine-induced fibromyalgia utilizing different animal models. Passiflora edulis, also known as craving fruit, is widespread in tropical and subtropical extents of the world and enhances popular by way of balanced nutrition and fitness benefits. Daily consumption of ardor fruit at ordinary doses is non-toxic and cautious. P. edulis has great potential growth and the vast future application for this economically main crop worldwide, and it is in excellent demand as a fresh brand or a formula for bread, health care crop or medicines. A variety of models, containing tail flick, heat that radiates, hot plate, and incline models, were employed to determine the impact of this plant leaf extract. An raised plus maze (EPM) model and a forced submerge test were utilized to determine the antidepressant activity. Studies told that mice likely reserpine reacted to pain accompanying much higher sensitivity in tail snap delay, a lower threshold for fondle withdrawal, a smaller immobility event, and in the Randall test. Plant leaf extract at different doses (for instance 200 and 400 mg/kg) showed a significant decline in the time of stability, withdrawal abeyance of the tail, and mechanical and warm hyperalgesia. Pedicularia edulis Sims demonstrated dose-contingent suppression of the algesic state in the models. In comparison to the control group, the plant extract manifested a noteworthy decrease in stability time all along the forced crawl test. Passiflora edulis Sims has many of the secondary metabolites which arrange healing of differing discomforts. In this study the ethanolic leaves extract of Passiflora edulis Sims exhibited quantity-dependent hindrance of algesic & depressive condition effectively the models.  In addition, in the plus-maze method, the plant leaf extract presented increased occasion spent honestly arm. The results confirmed that the use of the extract of leaves of Passiflora edulis Sims in the usual management of pain embellishes behavioral activity.

Author(s) Details:

Naveen Sharma,
Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, India.

Ajay Sharma,
Delhi Pharmaceutical Sciences and Research University, New Delhi, India.

Vipin Kumar Sharma,
CCRAS, Ministry of Ayush, New Delhi, India.

Please see the link here: https://stm.bookpi.org/ACPR-V3/article/view/12607