The circadian modulation of systemic inflammation is mediated by macrophages. Since the circadian clock directly controls macrophage functions at the molecular level, a circadian misalignment changes the macrophages' phenotype from a "protecting" mode to a "killing" mode. It is significant to note that pro-inflammatory macrophages cause systemic and chronic inflammation, which promotes the onset of a variety of chronic diseases and weakens the immune system's defences against infectious diseases like COVID-19. Under long-term circadian rhythm disruption, immune cells, particularly macrophages, undergo functional remodelling that exacerbates the development of inflammatory and infectious disorders as well as cancer, metabolic, cardiovascular, and aging-related diseases. The molecular mechanisms underpinning the circadian clock regulation of macrophage functions and the involvement of circadian rhythms in the emergence of inflammatory and infectious illnesses are being revealed by mounting data. This chapter attempts to highlight the most recent findings on the circadian regulation of macrophage functions and to address the possible effects of macrophage rejuvenation that targets the circadian system.
Author(s) Details:
Ken Shirato,
Department of Molecular Predictive Medicine and Sport Science, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo-181-8611, Japan
Shogo Sato,
Department of Biology, Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA.
Please see the link here: https://stm.bookpi.org/RABS-V8/article/view/8191
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