This study's objective was to evaluate the effectiveness and
security of cyclosporine for the treatment of severe cutaneous adverse drug
reactions (sCADR). In a tertiary care facility in South India, the department
of dermato-venereo-leprology undertook a three-year retrospective research. Of
the 34 in-patients who encountered adverse medication reactions, 20 patients
(one DRESS, ten SJS, and nine TEN patients) who matched the inclusion criteria
were selected for the research (ADRs). The offending drug(s) were withheld,
standard investigations were carried out, and SCORTEN was used to determine the
severity. Additionally excluded were TEN with multiorgan failure and fixed drug
eruption. To begin the course of therapy, dexamethasone injections at a dosage
of 1 mg/kg per day were given. If not contraindicated, oral cyclosporine was
given at a dose of 100 mg once a day for two weeks, then it was lowered to 50
mg a week and stopped after the lesions had healed in patients who had not
reacted satisfactorily after three days. The efficacy of cyclosporine was
assessed using the average number of stabilisation days, the rate of cutaneous
re-epithelialization, and the length of hospitalisation. With the
administration of cyclosporine, patients stabilised more rapidly, and
re-epithelialization occurred sooner; concomitant steroid therapy helped with
the early reduction of steroid dosage. Both the hospital stay and the
recuperation time were cut short. Cyclosporine was not related with any deaths,
and it appeared to be safe.
Author(s) Details:
V. Anandan,
Dept. of Dermatology, Government Stanley Hospital, Chennai, Tamilnadu, India.
Afthab Jameela Wahab,
Dept. of
Dermatology, Government Stanley Hospital, Chennai, Tamilnadu, India.
P. S.
Mohana Sundari,
Dept. of
Dermatology, Government Stanley Hospital, Chennai, Tamilnadu, India.
Yoga
Nandhini,
Dept. of
Dermatology, Government Stanley Hospital, Chennai, Tamilnadu, India.
Ragini
Rajan,
Dept. of
Dermatology, Government Stanley Hospital, Chennai, Tamilnadu, India.
Please see the link here: https://stm.bookpi.org/CODHR-V2/article/view/7748
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