It has been seventeen years since the publication of
single-cell genomic analysis, a systematic overview of single-cell approaches
integrating genomic and proteomic investigations. Molecular pathology,
molecular genetics, forensic medicine, and biomarker discovery have all
benefited from the application of single-cell techniques with downstream
genomic and proteomic analyses. Additionally, the dynamic cell-sorting method
has made significant strides in the therapeutic domains of cancer stem cell
differentiation, regeneration medicine, and downstream cell culture and genetic
research of stem cells. Furthermore, advanced cancer illness has been treated
using tissue level sampling and in silico analysis. Physicians and scientists
can now use one of these techniques with genomic analysis in their clinical
areas of research thanks to recent developments in homogeneous cell sorting in
vitro (or single cells technique), ex vivo (dynamic analysis or small number of
cell cultures with downstream genomic analysis), and in silico (tissue level
sampling with in silico analysis). In order to fully understand these
contemporary procedures, this manual will explain recently established
techniques of clinical genomic analysis in vitro, in silico, and ex vivo. The
author of the review study also goes through how to use these techniques in
various clinical settings. Some of the problems that mixed cells from clinical
specimens provide for clinical genomics analysis and diagnosis will eventually
be addressed in the manual.
Author(s) Details:
Biaoru Li,
Department Pediatrics, Georgia Cancer Center, MCG, Augusta, GA
30912, Georgia.
Please see the link here: https://stm.bookpi.org/CPMS-V5/article/view/7671
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