Over the years, chromosomal aneuploidies linked to advanced maternal age have been widely discussed and contested. With limited evidence, the paternal age effect linked with aneuploidies was underreported, leaving room for investigation and disagreement. In a retrospective investigation, the researchers looked at the paternal age of three chromosomal aneuploidies in the Indian population. With confirmed karyotype, the paternal age was added in the patient data. The paternal age was split into two categories: under 30 years and above 30 years. The relationship between paternal age and children born with aneuploidies was investigated using linear regression analysis. Paternal age was statistically significant as a confounding risk factor in chromosomal aneuploidy in both age groups for Down and Turner syndrome, according to the researchers. These findings highlighted the need of treating couples who are at risk of cytogenetic abnormalities in a targeted manner. The link between chromosomal aneuploidies and the influence of young paternal age is an intriguing element that should be investigated further and discussed by future researchers.
Author (S) Details
Sayee Rajangam
St. John’s Medical College, Bengaluru, Karnataka, India.
Leelavathy Nanjappa
Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
C. Lalitha
Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India.
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