Microanatomy of Human Foetal Pancreatic Tissue: A Chronological Study | Chapter 10 | New Visions in Biological Science Vol. 1

 Introduction: The name pancreas derives from the Greek word pankreas, which means "pancreas of the stomach." Diabetes mellitus and pancreatic cancer are both pancreatic diseases. It consists of Endocrine cells, also known as Islets of Langerhans, which secrete insulin, glucagon, and somatostatin, all of which aid in blood glucose regulation [1]. Pancreatic enzymes and alpha fetoprotein are released by exocrine pancreatic acini, which govern pancreas growth and differentiation by varying expression levels during development [2]. Endocrine disease is the cause of diabetes, which affects at least 200 million people worldwide and is anticipated to quadruple by 2025 [1]. Pancreatic cancer, which kills over 65,000 people in Europe each year and is usually incurable, is caused by the exocrine part.

The purpose of this study was to examine the microanatomy (Histogenesis) of the pancreas in aborted fresh human embryos with no congenital defects. As a result, the current research was conducted in order to understand more about the development of acini and islets, as well as their clinical relationship.

Fetuses were gathered from the Obstetrics and Gynecology department of Kamineni Institute of Medical Sciences, Narkatpally, Nalgonda (Dt), Telangana, (India) and Kamineni Academy of Medical Sciences and Research Centre, L.B. Nagar, Hyderabad.

Although multiple investigations have demonstrated that pancreatic islets are required for pancreas transplantation, only a few studies have established that pancreatic acini are also required.

In the early stages of development, the parenchyma produces primitive tubules with small lobes and acini lobules, as well as small spherical islets (12-18 weeks). Due to encapsulation and acinar cell proliferation, the size and quantity of Islets grow with age (18-24 weeks).

To summarise, at the age of 18-24 weeks, the foetal pancreas is eligible for organ transplantation in individuals with diabetes mellitus and pancreatic cancer.

Author (S) Details

T. V. Ramani
Kamineni Academy of Medical Sciences and, Research Centre, Hyderabad, India.

M. Pratyusha
Shadan Institute of Medical Sciences, Hyderabad, Telangana, India.

S. Saritha
Department of Anatomy, Kamineni Academy of Medical Sciences and, Research Centre, Hyderabad, India.

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