Sepsis is a medical emergency that describes the body's systemic immunological response to an infection, which can lead to organic dysfunction and death. Sepsis is a severe, high-prevalence, severe, and health-care-burdening inflammatory illness.
Sepsis remains one of the primary causes of morbidity and mortality in critically sick patients, despite progress in understanding the pathophysiology of the illness and treatment.
Early detection and management are critical for better outcomes, which inspired the concept of the "golden hour," during which shock and organic malfunction can be corrected to improve patient outcomes. However, the earliest symptoms of sepsis are frequently ambiguous, making it difficult to determine the severity of the condition. Systemic inflammatory response syndrome manifests as abnormalities in temperature, heart and respiration rates, and leukocyte counts (SIRS).
Diagnosis, care, and follow-up of sepsis patients are difficult, and a number of biomarkers, such as lactic acid, procalcitonin, C-reactive protein, and immature granulocytes, have been proposed for early diagnosis and prognosis of septic patients. Leukocytes interact with endothelium cells, causing a humoral, cellular, and neuroendocrine reaction in the host. New leukocyte-derived parameters are emerging as potentially useful markers in various clinical situations. The new generation of hematological analyzers incorporates technological innovations that allow to expand the information derived from the complete blood count: new leukocyte-derived parameters are emerging as potentially useful markers in various clinical situations.
Additional analysis criteria Cell Population Data (CPD) has just been available, which characterizes diverse leukocyte populations. preliminary data suggest they could be effective in the diagnosis of sepsis The importance of CPD for early diagnosis of sepsis, as stated by current cellular counters, and hence the potential improvement in patient outcomes, is highlighted in this review.Author (s) Details
Eloísa Urrechaga
Biocruces Bizkaia Research Institute, Cruces Plaza, 48903 Barakaldo, Bizkaia, Spain.
View Book : - https://stm.bookpi.org/HMMR-V9/article/view/1024
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